Affiliation:
1. Universidade Estadual Paulista (UNESP), Brazil
2. Universidade de São Paulo (USP), Brazil
Abstract
Abstract Polymethylmethacrylate bone cement is a standard material used as antibiotic carrier in the orthopedic surgery. The ultrasonic energy method is capable of triggering biological effects based on both thermal and non-thermal mechanisms. The aim of the current study is to analyze methylene blue dispersion in polymethylmethacrylate beads, in association with the acoustic field generated by non-thermal ultrasound. Forty-nine specimens were used, and each specimen comprised one polymethylmethacrylate bead (0.6-mm diameter) doped with methylene blue and deposited in gelatin sample. Forty test specimens were divided into four groups comprising 10 samples, each, based on different ultrasound intensities (Group 1: 1.0 W/cm2; Group 2: 1.5 W/cm2) and polymethylmethacrylate bead depths (A - 2 cm; B - 3 cm) in gelatin sample. The control group comprised other nine specimens and statistically differed from the other groups. All groups irradiated with ultrasound have shown statistically significant differences in methylene blue dispersion, except for Groups 2A and 2B. Methylene blue dispersion in gelatin among groups was 1A> 1B; 2A> 1A; 2B> 1A; 2A> 1B; and 2B> 1B. Low-intensity ultrasound enabled the highest methylene blue dispersion when polymethylmethacrylate bead was positioned superficial; bead depth associated with high-intensity ultrasound did not influence methylene blue dispersion.
Subject
General Veterinary,Animal Science and Zoology
Reference22 articles.
1. Local antibiotic therapy in osteomyelitis;Gogia JS;Seminars in Plastic Surgery,2009
2. Osteomyelitis: an overview of antimicrobial therapy;Gomes D;Brazilian Journal of Pharmacology Science,2013
3. Novel antibiotic delivery and novel antimicrobials in prosthetic joint infection;Mihok P;Journal of Traumatology and Orthopedics,2016
4. Biodegradable scaffolds for bone regeneration combined with drug-delivery systems in osteomyelitis therapy;Dorati R;Pharmacology (Basel),2017
5. Advances in the local and targeted delivery of anti-infective agents for management of osteomyelitis;Ford CA;Expert Review of Anti-infective Therapy,2017