Cognitive assessment in patients with Hepatitis C submitted to treatment with Sofosbuvir and Simeprevir or Daclatasvir

Author:

GASCON Maria Rita Polo1ORCID,BENUTE Glaucia Rosana Guerra1ORCID,MACEDO Elizeu Coutinho2ORCID,CAPITÃO Claudio Garcia3ORCID,VIDAL José Ernesto4ORCID,SMID Jerusa3ORCID,MARCUSSO Rosa Maria Nascimento3ORCID,LUCIA Mara Cristina Souza de5,PENALVA-DE-OLIVEIRA Augusto Cesar3ORCID,DIAMENT Decio3ORCID

Affiliation:

1. Universidade de São Paulo, Brazil

2. Universidade Presbiteriana Mackenzie, Brazil

3. Instituto de Infectologia Emilio Ribas, Brazil

4. Universidade de São Paulo, Brazil; Instituto de Infectologia Emilio Ribas, Brazil

5. Centro de Estudos Psicologia Saúde, Brazil

Abstract

ABSTRACT Background: Hepatitis C can be defined as an infectious disease that develops an inflammatory activity, which may cause an impairment in the central nervous system, may cause cognitive impairments and symptoms of depression. Objective: The objective of this study was to verify the cognitive performance of patients with chronic hepatitis C before and after treatment with simeprevir, sofosbuvir, and daclatasvir. Methods: A prospective study was carried out in three stages: before, right after treatment, and six months after. Fifty-eight patients under clinical follow-up were evaluated at the Emílio Ribas Infectology Institute, in São Paulo, Brazil. The following instruments were used: sociodemographic questionnaire, Lawton’s Scale, Beck’s Depression Inventory, and a battery of neuropsychological tests that evaluated: intellectual function, memory, attention, executive function, and motor and processing speed). For statistical analysis, the analyses described (mean, frequency, and standard deviation), chi-square, and ANOVA were used. Results: Most of the participants were male (n=30, 51.7%), with a mean of 58.23±8.79 years, mean schooling of 9.75±4.43 years. Comparing the results of neuropsychological evaluations (before, just after completion of drugs, and six months), a significant improvement was observed in relation to the acquisition of new knowledge (p=0.03), late visual memory (p=0.01), and tendency towards alternate attention (p=0.07). Conclusion: The treatment of the hepatitis C virus improved cognitive performance, especially in relation to memory.

Publisher

FapUNIFESP (SciELO)

Subject

Neurology,Clinical Neurology

Reference40 articles.

1. Programa Nacional de DST e AIDS - Boletim Epidemiológico - Hepatites Virais de 2018

2. Estimated prevalence of viral hepatitis in the general population of the Municipality for review only Sao Paulo, measured by a serologic survey of a stratified, randomized and residence based population;Focaccia R;Braz J Infect Dis,1998

3. Epidemiologia da infecção pelo vírus da hepatite C;Martins T;Rev Ass Med Bras,2011

4. Neuropsychological impairment in patients with chronic hepatitis C;Hilsabeck RC;Hepatology,2002

5. Cognitive functioning and psychiatric symptomatology in patients with chronic hepatitis C;Hilsabeck RC;J Int Neuropsychol Soc,2003

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3