Motor and non-motor wearing-off and its impact in the quality of life of patients with Parkinson's disease-Reference-Cited by-同舟云学术

Motor and non-motor wearing-off and its impact in the quality of life of patients with Parkinson's disease

Published:2018-08 Issue:8 Volume:76 Page:517-521
ISSN:1678-4227
Container-title:Arquivos de Neuro-Psiquiatria
language:
Short-container-title:Arq. Neuro-Psiquiatr.

Author:

Rodríguez-Violante Mayela¹,Ospina-García Natalia²,Dávila-Avila Ned Merari²,Cruz-Fino Diego²,Cruz-Landero Alejandra de la²,Cervantes-Arriaga Amin²

Affiliation:

1. Instituto Nacional de Neurología y Neurociurgía, Mexico; Instituto Nacional de Neurología y Neurociurgía, Mexico

2. Instituto Nacional de Neurología y Neurociurgía, Mexico

Abstract

ABSTRACT The wearing-off phenomenon is common in patients with Parkinson's disease. Motor and non-motor symptoms can fluctuate in relation to the “on/off” periods. Objective: To assess the impact of motor and non-motor wearing-off on activities of daily living and quality of life of patients with PD. Methods: A cross-sectional study was carried out. All patients were evaluated using the Movement Disorders Society Unified Parkinson's Disease Rating Scale. Wearing-off was assessed using the Wearing-Off Questionnaire-19, and quality of life was assessed using the Parkinson's Disease Questionnaire-8. Results: A total of 271 patients were included; 73.4% had wearing-off; 46.8% had both motor and non-motor fluctuations. Patients with both motor and non-motor wearing-off had a worst quality of life compared with those with only motor fluctuations (p = 0.047). Conclusions: Motor and non-motor fluctuations have an impact on activities of daily living and quality of life. Non-motor wearing-off may have a higher impact.

Publisher

FapUNIFESP (SciELO)

Subject

Neurology,Neurology (clinical)

Link

http://www.scielo.br/pdf/anp/v76n8/0004-282X-anp-76-08-0517.pdf

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