Is phrenic nerve conduction affected in patients with difficult-to-treat asthma?

Author:

Maranhão Analúcia Abreu1,Rodrigues Marcia Maria Jardim2,Carvalho Sonia Regina da Silva1,Caetano Marcelo Ribeiro2,Compagnoni Inaê Mattoso3,Carnio Tatiane Katia3,Ribeiro Débora3

Affiliation:

1. Universidade Federal do Estado Rio de Janeiro, Brasil; Universidade Federal do Estado Rio de Janeiro, Brasil

2. Universidade Federal do Estado Rio de Janeiro, Brasil

3. Rio de Janeiro State Federal University, Brazil

Abstract

ABSTRACT Objective The aim of this study was to obtain data on phrenic neuroconduction and electromyography of the diaphragm muscle in difficult-to-treat asthmatic patients and compare the results to those obtained in controls. Methods The study consisted of 20 difficult-to-treat asthmatic patients compared with 27 controls. Spirometry, maximal inspiratory and expiratory pressure, chest X-ray, phrenic neuroconduction and diaphragm electromyography data were obtained. Results The phrenic compound motor action potential area was reduced, compared with controls, and all the patients had normal diaphragm electromyography. Conclusion It is possible that a reduced phrenic compound motor action potential area, without electromyography abnormalities, could be related to diaphragm muscle fiber abnormalities due to overload activity.

Publisher

FapUNIFESP (SciELO)

Subject

Neurology,Neurology (clinical)

Reference21 articles.

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3. Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma;Chung KF;Eur Respir J,1999

4. Economic burden of asthma: a systematic review;Bahadori K;BMC Pulm Med,2009

5. Complex lung function in severe asthma: seeing is believing;King GG;Eur Respir J,2016

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