Affiliation:
1. Universidade de Brasília, Brazil
2. Universidade Federal do Rio Grande do Norte, Brazil
3. UnB, Brazil
Abstract
Abstract: Mammary gland tumors are the most common type of tumors in bitches but research on survival time after diagnosis is scarce. The purpose of this study was to investigate the relationship between survival time after mastectomy and a number of clinical and morphological variables. Data was collected retrospectively on bitches with mammary tumors seen at the Small Animal Surgery Clinic Service at the University of Brasília. All subjects had undergone mastectomy. Survival analysis was conducted using Cox's proportional hazard method. Of the 139 subjects analyzed, 68 died and 71 survived until the end of the study (64 months). Mean age was 11.76 years (SD=2.71), 53.84% were small dogs. 76.92% of the tumors were malignant, and 65.73% had both thoracic and inguinal glands affected. Survival time in months was associated with age (hazard rate ratios [HRR] =1.23, p-value =1.4x10-4), animal size (HRR between giant and small animals =2.61, p-value =0.02), nodule size (HRR =1.09, p-value =0.03), histological type (HRR between solid carcinoma and carcinoma in a mixed tumor =2.40, p-value =0.02), time between diagnosis and surgery (TDS, with HRR =1.21, p-value =2.7x10-15), and the interaction TDS*follow-up time (HRR =0.98, p-value =1.6x10-11). The present study is one of the few on the subject matter. Several important covariates were evaluated and age, animal size, nodule size, histological type, TDS and TDS*follow up time were identified as significantly associated to survival time.
Reference33 articles.
1. Cytologic differentiation of benign from malignant canine mammary tumors;Allen S.W.;Vet. Pathol.,1986
2. Avaliação imunoistoquímica da expressão da glicoproteína-P em tumores de mama de cadelas tratadas com prednisona;Andrade A.L.;Vet. Zootec.,2008
3. Neoplasia mamária em cadelas: caracterização histopatológica e expressão de proteínas de estresse (HSP 72);Carvalho T.B.,2006
4. Consensus for the diagnosis, prognosis and treatment of canine mammary Tumors;Cassali G.D.;Braz. J. Vet. Pathol.,2013
5. Fatores prognósticos no diagnóstico clínico e histopatológico dos tumores de mama em cadelas: uma revisão;Cavalcanti M.F.;Revta Clín. Vet.,2006
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献