In vitro evaluation of erythromycin in chloroquine resistant brazilian P. falciparum freshly isolates: modulating effect and antimalarial activity evidence-Reference-Cited by-同舟云学术

In vitro evaluation of erythromycin in chloroquine resistant brazilian P. falciparum freshly isolates: modulating effect and antimalarial activity evidence

Published:1999-07 Issue:4 Volume:41 Page:249-253
ISSN:0036-4665
Container-title:Revista do Instituto de Medicina Tropical de São Paulo
language:
Short-container-title:Rev. Inst. Med. trop. S. Paulo

Author:

MENEZES Carla M. S.¹,KIRCHGATTER Karin²,DI SANTI Sílvia M. F.²,SAVALLI Carine¹,MONTEIRO Fabíola G.¹,PAULA Gilberto A.¹,FERREIRA Elizabeth I.¹

Affiliation:

1. Universidade de São Paulo, Brasil

2. Superintendência de Controle de Endemias, Brasil

Abstract

Erythromycin, a reversal agent in multidrug-resistant cancer, was assayed in chloroquine resistance modulation. The in vitro microtechnique for drug susceptibility was employed using two freshly isolates of Plasmodium falciparum from North of Brazil. The antimalarial effect of the drug was confirmed, with an IC50 estimates near the usual antimicrobial therapy concentration, and a significant statistical modulating action was observed for one isolate.

Publisher

FapUNIFESP (SciELO)

Subject

Infectious Diseases,General Medicine

Link

http://www.scielo.br/pdf/rimtsp/v41n4/v41n4a10.pdf

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