In vitro susceptibility to antifungal agents of clinical and environmental Cryptococcus neoformans isolated in Southern of Brazil-Reference-Cited by-同舟云学术

In vitro susceptibility to antifungal agents of clinical and environmental Cryptococcus neoformans isolated in Southern of Brazil

Published:2001-10 Issue:5 Volume:43 Page:267-270
ISSN:0036-4665
Container-title:Revista do Instituto de Medicina Tropical de São Paulo
language:
Short-container-title:Rev. Inst. Med. trop. S. Paulo

Author:

ALVES Sydney Hartz¹,OLIVEIRA Loiva T.²,COSTA Jane M.²,LUBECK Irina¹,CASALI Agnes Kiesling³,VAINSTEIN Marilene Henning³

Affiliation:

1. Universidade Federal de Santa Maria, Brasil

2. Hospital Universitário de Santa Maria, Brasil

3. Universidade Federal do Rio Grande do Sul, Brasil

Abstract

The purpose of the present study was to compare the susceptibility to four antifungal agents of 69 Cryptococcus neoformans strains isolated from AIDS patients with that of 13 C. neoformans strains isolated from the environment. Based on the NCCLS M27-A methodology the Minimal Inhibitory Concentrations (MICs) obtained for amphotericin B, itraconazole and ketoconazole were very similar for clinical and environmental isolates. Clinical isolates were less susceptible to fluconazole than environmental isolates. The significance of these findings and aspects concerning the importance, role and difficulties of C. neoformans susceptibility testing are also discussed.

Publisher

FapUNIFESP (SciELO)

Subject

Infectious Diseases,General Medicine

Link

http://www.scielo.br/pdf/rimtsp/v43n5/a06v43n5.pdf

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