Distribution of hepatitis B virus genotypes and viral load levels in Brazilian chronically infected patients in São Paulo city-Reference-Cited by-同舟云学术

Distribution of hepatitis B virus genotypes and viral load levels in Brazilian chronically infected patients in São Paulo city

Published:2009-10 Issue:5 Volume:51 Page:269-272
ISSN:0036-4665
Container-title:Revista do Instituto de Medicina Tropical de São Paulo
language:
Short-container-title:Rev. Inst. Med. trop. S. Paulo

Author:

Alcalde Rosana¹,Melo Fernando Lucas²,Nishiya Anna³,Ferreira Suzete Cleusa⁴,Langhi Júnior Mario Dante⁴,Fernandes Simone Sena¹,Marcondes Luis Augusto¹,Duarte Alberto José Silva¹,Casseb Jorge⁵

Affiliation:

1. Universidade de São Paulo, Brasil

2. Instituto de Ciências Biomédicas II, Brasil

3. Fundação Pró-Sangue, Brasil

4. Santa Casa de São Paulo, Brasil

5. Universidade de São Paulo, Brasil; USP, Brasil

Abstract

The objective of the present study was to evaluate the serum viral load in chronically infected Hepatitis B virus (HBV) patients and to investigate the distribution of HBV genotypes in São Paulo city. Quantitative HBV-DNA assays and HBV genotyping have gained importance for predicting HBV disease progression, have been employed for assessing infectivity, for treatment monitoring and for detecting the emergence of drug resistance. Twenty-nine Brazilian patients with suspected chronic hepatitis B were studied, using real time PCR for viral load determination and direct DNA sequencing for the genotyping. The serology revealed chronic HBV infection in 22 samples. The HBV-DNA was positive in 68% samples (15/22). The phylogenetic analysis disclosed that eleven patients were infected with HBV genotype A, two with genotype F and two with genotype D. Thus, the genotype A was the most prevalent in our study.

Publisher

FapUNIFESP (SciELO)

Subject

Infectious Diseases,General Medicine

Link

http://www.scielo.br/pdf/rimtsp/v51n5/v51n5a06.pdf

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