Treatment of severe chromoblastomycosis with itraconazole and 5-flucytosine association

Author:

Antonello Vicente Sperb1,Silva Marcelo Campos Appel da1,Cambruzzi Eduardo1,Kliemann Dimas Alexandre1,Santos Breno Riegel1,Queiroz-Telles Flávio2

Affiliation:

1. Hospital Nossa Senhora da Conceição, Brazil

2. Universidade Federal do Paraná, Brazil

Abstract

Chromoblastomycosis is a chronic human melanized fungi infection of the subcutaneous tissue caused by traumatic inoculation of a specific group of dematiaceous fungi through the skin, often found in barefooted agricultural workers, in tropical and subtropical climate countries. We report the case of a male patient presenting a slow-growing pruriginous lesion on the limbs for 20 years, mistreated over that time, which was diagnosed and successfully treated as chromoblastomycosis. Besides the prevalence of this disease, treatment is still a clinical challenge.

Publisher

FapUNIFESP (SciELO)

Subject

Infectious Diseases,General Medicine

Reference23 articles.

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5. The combined effect of 5-fluorocytosine and amphotericin B in the therapy of murine cryptococcosis;Block ER;Proc Soc Exp Biol Med.,1973

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