Affiliation:
1. Universidade Federal de Mato Grosso do Sul, Brasil
2. Instituto de Pesquisa Evandro Chagas, Brasil
Abstract
Thirty cases of histoplasmosis observed at the University Hospital of the Federal University of Mato Grosso do Sul (HU-UFMS) from January 1998 to December 2005 are reported. Most (83.3%) of the patients were men, average 33.4 years old, 63.3% of them were born and living in Mato Grosso do Sul and 83.3% presented AIDS as an underlying disease. In almost all cases (96.7%) the disease occurred in its disseminated form and the most frequent clinical manifestations were: fever (83.3%), weight loss (70.0%), cough (63.3%), hepatomegaly and splenomegaly (40.0%), and lymph node enlargement (36.7%). The laboratory diagnosis was obtained in 29 patients by isolation of Histoplasma capsulatum from various clinical specimens cultivated in Sabouraud dextrose and brain heart infusion agar and in 16 patients the fungus was observed by direct microscopy of Giemsa-stained smears. The observed mortality was 40%. This is the first report in the literature of the occurrence of histoplasmosis in Mato Grosso do Sul State.
Subject
Infectious Diseases,General Medicine
Reference16 articles.
1. Prevalência de infecção pelo Histoplasma capsulatum e pelo Paracoccidioides brasiliensis em escolares, granjeiros e população indígena na região de Sidrolândia, MS;AGUIAR E.S.A.,2000
2. Histoplasmose em pacientes imunodeprimidos: estudo de 18 casos observados em Uberlândia, MG;BORGES A.S.;Rev. Soc. bras. Med. trop.,1997
3. Disseminated histoplasmosis in the acquired immune deficiency syndrome: clinical findings, diagnosis and treatment, and review of the literature;JOSEPH WHEAT L.;Medicine,1990
4. Current diagnosis of histoplasmosis;JOSEPH WHEAT L.;Trends Microbiol.,2003
5. Differences in histoplasmosis in patients with acquired immunodeficiency syndrome in the United States and Brazil;KARIMI K.;J. infect. Dis.,2002
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