Local adverse effects associated with the use of inhaled corticosteroids in patients with moderate or severe asthma

Author:

Pinto Charleston Ribeiro1,Almeida Natalie Rios2,Marques Thamy Santana3,Yamamura Laira Lorena Lima4,Costa Lindemberg Assuncao5,Souza-Machado Adelmir5

Affiliation:

1. Southwestern Bahia State University, Brazil

2. Bahia School of Medicine and Public Health, Brazil

3. Roberto Santos General Hospital, Brazil

4. Bahia State Health Department, Brazil

5. Federal University of Bahia, Brazil

Abstract

OBJECTIVE: To describe and characterize local adverse effects (in the oral cavity, pharynx, and larynx) associated with the use of inhaled corticosteroids (ICSs) in patients with moderate or severe asthma. METHODS: This was a cross-sectional study involving a convenience sample of 200 asthma patients followed in the Department of Pharmaceutical Care of the Bahia State Asthma and Allergic Rhinitis Control Program Referral Center, located in the city of Salvador, Brazil. The patients were ≥ 18 years of age and had been using ICSs regularly for at least 6 months. Local adverse effects (irritation, pain, dry throat, throat clearing, hoarseness, reduced vocal intensity, loss of voice, sensation of thirst, cough during ICS use, altered sense of taste, and presence of oral candidiasis) were assessed using a 30-day recall questionnaire. RESULTS: Of the 200 patients studied, 159 (79.5%) were women. The mean age was 50.7 ± 14.4 years. In this sample, 55 patients (27.5%) were using high doses of ICS, with a median treatment duration of 38 months. Regarding the symptoms, 163 patients (81.5%) reported at least one adverse effect, and 131 (65.5%) had a daily perception of at least one symptom. Vocal and pharyngeal symptoms were identified in 57 (28.5%) and 154 (77.0%) of the patients, respectively. The most commonly reported adverse effects were dry throat, throat clearing, sensation of thirst, and hoarseness. CONCLUSIONS: Self-reported adverse effects related to ICS use were common among the asthma patients evaluated here.

Publisher

FapUNIFESP (SciELO)

Subject

Pulmonary and Respiratory Medicine

Reference24 articles.

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2. Diretrizes da Sociedade Brasileira de Pneumologia e Tisiologia para o Manejo da Asma 2012;J Bras Pneumol,2012

3. Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma;Buhl R;Allergy,2006

4. Adverse effects of inhaled corticosteroids;Hanania NA;Am J Med,1995

5. The local side effects of inhaled corticosteroids: current understanding and review of the literature;Roland NJ;Chest,2004

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