Affiliation:
1. Federal University of Minas Gerais, Brazil
Abstract
We report a rare case in a female infant (age, 3.5 months) with primary immunodeficiency (IFN-γ/IL-12 pathway defect) who presented with suppurative lymphadenitis after Mycobacterium bovis BCG vaccination. The strain of M. bovis BCG identified was found to be resistant to isoniazid and rifampin. The patient was treated with a special pharmacological regimen involving isoniazid (in a limited, strategic manner), ethambutol, streptomycin, and IFN-γ, after which there was complete resolution of the lesions.
Subject
Pulmonary and Respiratory Medicine
Reference15 articles.
1. Manual de vigilância epidemiológica dos eventos adversos pós-vacinação. 2nd Ed.,,1998
2. BCG vaccine: WHO position paper;Wkly Epidemiol Rec,2004
3. Severe axillary lymphadenitis after BCG vaccination: alert for primary immunodeficiencies;Santos A;J Microbiol Immunol Infect,2010
4. Idiopathic disseminated bacillus Calmette-Guérin infection: a French national retrospective study;Casanova JL;Pediatrics,1996
5. Resistant Mycobacterium bovis bacillus Calmette-Guérin disease: implications for management of bacillus Calmette-Guérin Disease in human immunodeficiency virus-infected children;Hesseling AC;Pediatr Infect Dis J,2004
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