Affiliation:
1. Universidade Estadual de Goiás, Brazil
2. Universidade Federal de Goiás, Brazil
Abstract
Ketoconazole and fluconazole are two broad-spectrum azole antifungals used for the treatment of superficial and systemic mycoses. Embryotoxicity and teratogenicity have been reported in some studies when those drugs are administered at high doses to pregnant rats. The aim of this study was to present a comparative study of embryotoxic effects as well as the skeletal anomalies in fetuses of Wistar rats which received ketoconazole and fluconazole at teratogenic doses on gestational days (GD) 6 through 15 (organogenesis period). On gestational day (GD) 21, the dams were euthanized and examined for standard parameters of reproductive outcome. Fetuses were stained with alizarin red and the bones of the head, trunk, forelimb and hindlimb were examined for detection of skeletal anomalies. The frequency of skeletal anomalies in the ketoconazole-treated group was significant when compared to the fluconazole and the control group.
Reference22 articles.
1. Successful treatment with ketoconazole of Cushing's syndrome in pregnancy;Amado J.A.;Postgrad. Med. J.,1990
2. Cushing's syndrome in pregnancy treated by ketoconazole: case report and review of the literature;Berwaerts J.;Gynecol. Endocrinol.,1999
3. Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk;Briggs G.G.,1998
4. Pregnancy outcome in ketoconazole-treated rats and mice;Buttar H.S.;Teratology,1989
5. Correlation between maternal toxicity and embryo/fetal effects;Chahoud I.;Reprod. Toxicol.,1999
Cited by
17 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献