Basal ganglia lesions in subacute sclerosing panencephalitis

Author:

Almeida Kelson James1,Brucki Sonia Maria Dozzi1,Duarte Maria Irma Seixas2,Pasqualucci Carlos Augusto Gonçalves3,Rosemberg Sérgio3,Nitrini Ricardo1

Affiliation:

1. Cognitive Disorders Reference Center, Brazil

2. Laboratory of Transmissible Diseases Pathology, Brazil

3. University of São Paulo, Brazil

Abstract

ABSTRACT The parieto-occipital region of the brain is the most frequently and severely affected in subacute sclerosing panencephalitis (SSPE). The basal ganglia, cerebellum and corpus callosum are less commonly involved. We describe a patient with SSPE confirmed by neuropathology based on brain magnetic resonance imaging showing extensive basal ganglia involvement and no significant involvement of other cortical structures. Though rarely described in SSPE, clinicians should be aware of this involvement. SSPE should be kept in mind when changes in basal ganglia signal are seen on brain magnetic resonance imaging with or without involvement of other regions of the human brain to avoid erroneous etiological diagnosis of other pathologies causing rapidly progressive dementia.

Publisher

FapUNIFESP (SciELO)

Subject

Cognitive Neuroscience,Geriatrics and Gerontology,Clinical Neurology,Neurology,Sensory Systems

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