The effect of 677C>T and 1298A>C MTHFR polymorphisms on sulfasalazine treatment outcome in rheumatoid arthritis

Author:

Pawlik A.1,Kurzawski M.1,Gawronska-Szklarz B.1,Gornik W.1,Dziedziejko V.2,Safranow K.2,Juzyszyn Z.1,Drozdzik M.1

Affiliation:

1. Pomeranian Medical University

2. Pomeranian Medical University, Poland

Publisher

FapUNIFESP (SciELO)

Subject

Cell Biology,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Immunology,Physiology,Biochemistry,General Neuroscience,Biophysics

Reference22 articles.

1. Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications: results of a two-year, randomized, double-blind, placebo-controlled trial;O’Dell JR;Arthritis Rheum,2002

2. Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis;Kumagai K;Int J Mol Med,2003

3. Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis;Haagsma CJ;Ann Rheum Dis,1999

4. Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase;Kang SS;Am J Hum Genet,1988

5. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase;Frosst P;Nat Genet,1995

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