Pulmonary emphysema induced by methylphenidate: experimental study

Author:

Rapello Gabriel Victor Guimarães1,Antoniolli Andréia2,Pereira Daniel Martins1,Facco Gilberto3,Pêgo-Fernandes Paulo Manuel4,Pazetti Rogério5

Affiliation:

1. Hospital Regional de Mato Grosso do Sul, Brasil

2. Universidade Federal de Mato Grosso do Sul (UFMS), Brasil

3. Universidade Anhanguera-Uniderp, Brasil

4. Universidade de São Paulo, Brasil

5. Universidade de São Paulo (FMUSP), Brasil

Abstract

CONTEXT AND OBJECTIVE: Methylphenidate is the most widely used drug for treating attention deficit hyperactivity disorder. However, it has important side effects, such as abdominal pain, insomnia, anorexia and loss of appetite, and also some cases of early severe emphysema after drug abuse have been reported. Our aim was to investigate the development of pulmonary emphysema in rats that were subjected to different doses of methylphenidate. DESIGN AND SETTING: Experimental study carried out at the laboratory of a public university. METHODS: Eighteen male Wistar rats were divided into three groups: control (0.9% saline solution); MP 0.8 (methylphenidate, 0.8 mg/kg); MP 1.2 (methylphenidate, 1.2 mg/kg). After 90 days of daily gavage, the animals were sacrificed and lung tissue samples were prepared for analysis on the mean alveolar diameter (Lm). RESULTS: The Lm was greater in MP 0.8 (47.91 ± 3.13; P < 0.01) and MP 1.2 (46.36 ± 4.39; P < 0.05) than in the control group (40.00 ± 3.48). CONCLUSION: Methylphenidate caused an increase in the alveolar diameter of rats, which was compatible with human pulmonary emphysema.

Publisher

FapUNIFESP (SciELO)

Subject

General Medicine

Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Acute or chronic pulmonary emphysema? Or both?—A contribution to the diagnosis of death due to violent asphyxiation in cases with pre-existing chronic emphysema;International Journal of Legal Medicine;2021-06-28

2. Methylphenidat: Ein Rückblick;Revista Científica Multidisciplinar Núcleo do Conhecimento;2021-05-17

3. Metilfenidato: una revisione;Revista Científica Multidisciplinar Núcleo do Conhecimento;2021-05-04

4. Metilfenidato: Una Revisión;Revista Científica Multidisciplinar Núcleo do Conhecimento;2021-05-04

5. Metilfenidato: Una recensione;Revista Científica Multidisciplinar Núcleo do Conhecimento;2021-05-04

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