Dental anomalies in the deciduous dentition of non-syndromic oral clefts patients

Author:

Tamburini Adriana Boeri Freire1ORCID,Rodrigues Ygor Henrique Pereira1ORCID,Martelli Daniella Reis Barbosa2ORCID,Barros Letízia Monteiro de1ORCID,Andrade Rodrigo Soares de3ORCID,Machado Renato Assis3ORCID,Coletta Ricardo Della3ORCID,Martelli-Júnior Hercílio2ORCID,Flório Flávia Martão4ORCID

Affiliation:

1. University of José RosárioVellano, Brazil

2. State University of Montes Claros, Brazil

3. University of Campinas, Brazil

4. Dental Research Center, Brazil

Abstract

Abstract Objectives: to investigate the prevalence of dental anomalies in complete deciduous dentition of children with NSCL/P. Methods: this study included 75 children with NSCL/P and 286 healthy control. In both groups the children had deciduous dentition with ages varying from 4 to 6 years. Clinical examination, panoramic and periapical radiographies were performed and dental anomalies of number and shape were considered. Results: there was a higher prevalence of dental anomalies in the case group, compared to the control group. In all, 42 dental anomalies were identified, 25.33% in the case group and 8.04% in control group (p<0.001). Therewas a higher frequency of dental anomalies in NSCL/P (47.36%), followed by non-syndromic cleft lip (31.57%) and non-syndromic cleft palate (21.05%). The occurrence of agenesis (p= 0.005) and twinning (p = 0.029) were higher in the case group. Conclusions: the occurrence of agenesis and dental twinning was more frequent in the case group and may contribute to the definition of oral cleft subphenotype.

Publisher

FapUNIFESP (SciELO)

Subject

Public Health, Environmental and Occupational Health,Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health

Reference30 articles.

1. Cleft lip and palate understanding genetic and environmental influences;Dixon MJ;Nat Rev Genet,2011

2. Prevalence of nonsyndromic oral clefts in a reference hospital in the state of Minas Gerais, Brazil, between 2000-2005;Martelli-Junior H;Braz Oral Res,2007

3. Prevalence of orofacial clefts and social factors in Brazil;Rodrigues K;Braz Oral Res,2009

4. Biological mechanisms in palatogenesis and cleft palate;Meng L;J Dent Res,2009

5. Clinical relevance of breast and gastric cancer-associated polymorphisms as potential susceptibility markers for oral clefts in the Brazilian population;Machado RA;BMC Med Genet,2017

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