Anaphylaxis with Schistosoma mansoni extracts in normal and infected mice

Author:

Mota-Santos T. A.1,Oliveira A. F. S.,Gerken S. E.1,Vaz N. M.1

Affiliation:

1. UFMG, Brasil

Abstract

Methods generally utilized for studies on anaphylaxis to protein antigens such as determination of histamine release to the blood, hemoconcentration, histamine release from peritoneal mast cells and passive cutaneous anaphylaxis (PCA) were used to investigate some aspects of the anaphylaxis to parasite antigens in Schistosoma mansoni infected mice. The release of histamine to the blood and significant rates of hemoconcentration were induced by intravenous injection of schistosomula or cercarial extracts into 10-13 weeks infected mice. Cercarial, schistosomula, worm tegument and soluble egg antigens were able to trigger histamine release from peritoneal mast cells from chronically infected mice. In spite of the PCA reaction beeing detected within 2 hours of sensitization (IgG1antibodies) in 6 of 8 tested sera from chronically infected mice, no detectable reactions were obtained after 48 hours sensitization (IgE antibodies). Although IgE was not detected in the circulation, by the PCA technique, the results indicate that the infected mice contained IgE antibodies bound to their mast cells.

Publisher

FapUNIFESP (SciELO)

Subject

Infectious Diseases,General Medicine

Reference29 articles.

1. Studies on the mechanism of self-cure reactions in rat infected with Nippostrongylus brasiliensis;BARTH E. E. E.;Immunol.,1965

2. Antigenic properties of purified fractions from Ascaris lumbricoides var. suum on naturally-sensitized guinea pigs;BERALDO W. T.;Brit. Pharmacol.,1961

3. Circulatory collapse in anaphylaxis and histamine toxicity in mice;BERGMAN R. K.;Immunol.,1965

4. Characterization of allergens in Schistosoma mansoni, Fasciola hepatica and Echinococcus granulosus;BOUT D.;Ann. Immunol. (Inst. Pasteur),1977

5. Observações sobre a infecção do camundongo pelo Schistosoma mansoni;BRENER Z.;Rev. Bras. Med. Mal. Doenças Trop.,1956

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3