Hepatic regeneration after partial hepatectomy in mice infected with Schistosoma mansoni, at the acute and chronic phases of the disease

Author:

COSTA G.1,CUNHA-MELO J.R.2,AGUIAR B.G.1,GONÇALVES S.C.1,TOPPA N.H.1,COELHO P.M.Z.3

Affiliation:

1. Federal University of Minas Gerais, Brazil

2. Federal University of Minas Gerais, Brazil; Federal University of Minas Gerais, Brazil

3. Federal University of Minas Gerais, Brazil; Santa Casa de Misericórdia, Brazil

Abstract

Outbred male albino mice normal or infected with 30 cercariae of Schistosoma mansoni (LE strain) were submitted to 65% hepatectomy during the acute (70 days) and chronic phase (160 days) phases of the disease. A group of the infected animals was treated with 400 mg/kg of oxamniquine during the acute phase before hepatectomy. Non-infected, infected and treated but not hepatectomized animals were kept as controls. Hepatic regeneration was evaluated by incorporation of tritiated thymidine, intraperitoneally injected into non-hepatectomized and hepatectomized animals, 24 hours after surgery. The results showed that removal of 65% of the hepatic parenchyma, during the acute phase, led to a statistically significant increase of thymidine incorporation, when compared with the uninfected hepatectomized controls. This phenomenon was not observed at the chronic phase. Treatment with oxamniquine administered during the acute phase led to a decrease in thymidine incorporation rate 160 days after infection (90 days after treatment) and 24 hours after hepatectomy. The data suggest that infection with S. mansoni represents a considerable stimulus for the regenerative capacity of the liver during the acute, but not the chronic phase of disease.

Publisher

FapUNIFESP (SciELO)

Subject

Infectious Diseases,General Medicine

Reference29 articles.

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2. Immunopathology of Schistosoma mansoni infection;BOROS D.L.;Clin. Microbiol. Rev.,1989

3. Experimental aspects of hepatic regeneration;BUCHER N.R.L.;New Engl. J. Med.,1967

4. The rate of incorporation of labelled thymidine into the deoxyribonucleic acid of regenerating rat liver in relation to amount of liver excised;BUCHER N.R.L;Cancer Res.,1964

5. The role of cytokines in the pathogenesis of hepatic granulomatous disease in Schistosoma mansoni infected mice;CHEEVER A.W.;Mem. Inst. Oswaldo Cruz,1992

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