Safety and immunogenicity of hepatitis B vaccine ButaNG in adults-Reference-Cited by-同舟云学术

Safety and immunogenicity of hepatitis B vaccine ButaNG in adults

Published:1999-05 Issue:3 Volume:41 Page:191-193
ISSN:0036-4665
Container-title:Revista do Instituto de Medicina Tropical de São Paulo
language:
Short-container-title:Rev. Inst. Med. trop. S. Paulo

Author:

IOSHIMOTO Luzia M.¹,RISSATO Maria Lúcia²,BONILHA Valentina S.J.²,MIYAKI Cosue¹,RAW Isaias³,GRANOVSKI Nikolai⁴

Affiliation:

1. Instituto Butantan, Brazil

2. Fundação Amaral Carvalho, Brazil

3. Fundação Butantan, Brazil

4. N.G.Biotecnologia Ltd, Brazil

Abstract

Recombinant yeast-derived hepatitis B vaccine manufactured by Instituto Butantan was administered in two groups of adult volunteers (I, II) following two different schedules of immunization. In the first trial (10 mg doses and 0, 1, 3 months vaccination schedule) 106 individuals completed the full immunization program. The results of seroconversion by age group varied from 70 to 100% and the GMT from 46.5 to 124.9 mIU mL-1. In the second trial with 68 individuals (for dosage comparison and 0, 1, 6 months vaccination schedule) indicated that the vaccine formulated in 20 mg was more effective than in 10 mg. The adverse reactions observed in the vaccinees were less frequent than the ones previously found since the introduction of similar vaccines.

Publisher

FapUNIFESP (SciELO)

Subject

Infectious Diseases,General Medicine

Link

http://www.scielo.br/pdf/rimtsp/v41n3/41n3a11.pdf

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