Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment
Author:
Affiliation:
1. Universidad de la República, Uruguay
2. Universidad Nacional de Asunción, Paraguay
3. Universidad de la República, Uruguay; Universidad de la República, Uruguay
Publisher
FapUNIFESP (SciELO)
Subject
Microbiology (medical)
Link
http://www.scielo.br/pdf/mioc/v113n3/0074-0276-mioc-113-03-0153.pdf
Reference30 articles.
1. Potent and selective inhibitors of Trypanosoma cruzi triosephosphate isomerase with concomitant inhibition of cruzipain: inhibition of parasite growth through multitarget activity;Aguilera E;Chem Med Chem,2016
2. Development of bis-thiazoles as inhibitors of triosephosphate isomerase from Trypanosoma cruzi. Identification of new non-mutagenic agents that are active in vivo;Álvarez G;Eur J Med Chem,2015
3. Identification of a new amide-containing thiazole as a drug candidate for treatment of Chagas' disease;Álvarez G;Antimicrob Agents Chemother,2015
4. Optimization of antitrypanosomatid agents: identification of nonmutagenic drug candidates with in vivo activity;Álvarez G;J Med Chem,2014
5. A combination of benznidazole and ketoconazole enhances efficacy of chemotherapy of experimental Chagas' disease;Araújo MSS;J Antimicrob Chemother,2000
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3. Prodrugs as new therapies against Chagas disease: in vivo synergy between Trypanosoma cruzi proline racemase inhibitors and benznidazole;Journal of Global Antimicrobial Resistance;2022-03
4. Chagas Disease Chemotherapy: What Do We Know So Far?;Current Pharmaceutical Design;2021-10-25
5. Recent Advances in the Development of Triose Phosphate Isomerase Inhibitors as Antiprotozoal Agents;Current Medicinal Chemistry;2021-09-13
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