Affiliation:
1. Universidade Estadual Paulista, Brasil
2. Instituto Lauro de Souza Lima
Abstract
We have studied the role of the immune response in the morphology of the leishmaniotic granuloma induced in the cheek pouch of hamsters, an immunologically privileged site, after inoculation of 3 x 10(5) Leishmania mexicana. Animals were histologically and immunologically evaluated until 120 days after inoculation. Independent of the time of sacrifice, the animals were always non-reactors to the footpad test (FPT). At histology, the introduction of L. mexicana in the cheek pouch leads to an abscess that evolves to a granulomatous reaction rich in amastigote forms, and later it leads to resolution, even in the absence of immune response detectable by FPT. Our results demonstrate that the development of immune response is not preponderant for the control of infection induced by L. mexicana inoculated subcutaneously in the cheek pouch of the hamster. It also suggests that the macrophages present in the leishmaniotic granuloma are capable of eliminating this parasite, even in the absence of immune response evaluated by FPT.
Subject
Infectious Diseases,Microbiology (medical),Parasitology
Reference20 articles.
1. The granulomatous inflammatory response: A review;Adams DO;American Journal of Pathology,1976
2. Immunopathology of experimental cutaneous leishmaniasis;Andrade ZA;American Journal of Pathology,1984
3. Experimental paracoccidioidomycosis in Syrian hamster inoculated in the cheek pouch;Arruda MSP;Mycopathologia (Den Haag),1994
4. Inoculation of the Mycobacterium leprae into the hamster cheek pouch;Arruda MSP;Leprosy Review,1994
5. The hamster cheek pouch: an immunologically privileged site suitable to the study of granulomatous infections;Arruda MSP;Revista do Instituto de Medicina Tropical de São Paulo,1995
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