Trypanosoma (herpetosoma) Rangeli tejera, 1920: influence of host weight, size of inoculum, and route of infection upon experimental parasitemia

Author:

Tejero Felix,Galli Natiela,Urdaneta-Morales Servio

Abstract

To study the influence of host age, inoculum size, and route of infection on Trypanosoma (Herpetosoma) rangeli, 12 lots of 6.0 g albino mice (NMRI strain) were infected up. with from 25x10¹ to 25x10(6) trypomastigotes/gram body weight harvested from LIT medium. The lower inocula produced low but persistent parasitemias, while the higher inocula produced high levels of parasitemia that fell quickly, suggesting the mobilization of resistance mechanisms. In other experiments, i.p. inoculation produced higher parasitemias than s.c. inoculation, and 6.0 g mice had higher parasitemias than 16.0 or 26.0 g mice. Thus, a standard methodology would seem to be necessary in the study of the various strains and/or species that may make up the T. rangeli complex.

Publisher

FapUNIFESP (SciELO)

Subject

Infectious Diseases,Microbiology (medical),Parasitology

Reference22 articles.

1. Studies on Trypanosoma rangeli;Afiez N.,1920

2. Deposition, migration, and growth of T. rangeli in two mammals,1981

3. The relative virulence of Trypanosoma brucei to young and to adult white rats;Ashcroft MT;Annals of Tropical Medicine and Parasitology,1959

4. Contribuição ao estudo da terapêutica experimental da doença de Chagas;Brener Z.

5. Influence of dose of trypanosomes and of body weight in experimental infections of white rats with Trypanosoma rhodesiense;Corson JF;Annals of Tropical Medicine and Parasitology,1934

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