Affiliation:
1. University College of Pharmaceutical Sciences, India
Abstract
A novel "Powder Solution Technology" involves absorption and adsorption efficiency which makes use of liquid medications, drug suspensions admixed with suitable carriers, coating materials and formulated into free flowing, dry looking, non adherent and compressible powder forms. Based upon a new mathematical model expression, improved flow characteristics and hardness of the formulation has been achieved by changing the proportion of Avicel ® PH 200 and Aerosil ® PH 200 from 50:1 ratio to 5:1 and in which the drug is dispersed in an almost molecularly state. Due to their significantly improved wetting properties a greater drug surface area is exposed to the dissolution media, resulting in an increased dissolution rate and bio availability. By using the Liquisolid technique, sustained drug delivery systems were developed for the water soluble drugs in which hydrophobic non-volatile solvents are used as vehicles.
Subject
General Pharmacology, Toxicology and Pharmaceutics
Reference29 articles.
1. Deagglomeration behavior of relatively insoluble benzoic acid and its sodium salt;AGUIAR A. J.;J. Pharm. Sci.,1979
2. Dissolution rate enhancement of fenofibrate using liquisolid tablet technique;AMRIT KARMARKAR B.;Lat. Am. J. Pharm.,2009
3. Liquisolid tablets: a novel approach for drug delivery;AMRIT KARMARKAR B.;Int. J. Health Res.,2009
4. Soft gelatin capsules: unique dosage form;EBERT W. R.;Pharm. Tech.,1977
5. Dissolution kinetics of drugs in human gastric juice the role of surface tension;FINHOLT P.;J. Pharm. Sci.,1968
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