Efficacy and safety of a cosmeceutical regimen based on a combination of low molecular weight hyaluronic acid, placental peptides and extract of Malus domestica in improving signs of periorbital skin aging

Abstract

Background: Periorbital wrinkle formation is a relatively early sign of skin aging. The public interest in the reversal of aging has increased significantly among demanding patients and aesthetic practitioners within the past decades. However, many aesthetic patients, whether young or old, prefer to avoid invasive procedures wherever possible, seeking natural-looking results.Therefore, physicians have had to respond to their patient's expectations. Objectives: This study aimed to evaluate whether the synergistic anti-aging activity of MF3 Placenta 3R serum product has an influence towards the treating of wrinkles as well as skin hydration, and skin elasticity in the periorbital area. Methods: 23 healthy adult female volunteers were instructed to apply MF3 Placenta 3R serum containing a mixture of low molecular weight hyaluronic acid (LMWHA), placental peptides and extract of Malus domestica around the eye area twice daily during the study period of eight weeks. The skin measurements were performed in the periorbital area by investigating the skin elasticity (Cutometer) and skin hydration (Corneometer). Patients questionnaires were answered at 59 days. Results: The findings of the study proved a moisturizing impact of MF3 Placenta 3R serum throughout the trial that transformed into significant improvements in periocular skin hydration and elasticity. Conclusion: The tested formulation of MF3 Placenta 3R serum appears to be effective and may stimulate the periorbital skin rejuvenation in a women 44 – 52 years, resulting in the clinical appearance of smoother skin with less visible wrinkling. Further randomized, controlled studies have to be done to confirm these results.