Abstract
Background: Cardiac toxicity associated with oncology drugs, is a known risk, although multiple studies has been performed to detect this problem in an early stage, no definitive results has been achieved. We conducted a clinical study in a large number of patients with a longer follow-up, to evaluate if surveillance tests, such as 2D echocardiogram (ECHO) and radionuclide ventriculography (RNV) can detected early cardiac damage in patients who received anthracycline-based chemotherapy. Patients and methods: We conducted a cohort clinical study in 3073 patients with pathological confirmed of diffuse large B-cell lymphoma that had a complete response with a longer follow-up: 18. (Range 6.8 to 32.3) years: the mentioned test were performed periodically: every 6months the first 5years, an annually from 5years until relapse, death from any cause or last of follow-up, or the presence of congestive heart failure. Results: Asymptomatic abnormalities in surveillance studies, without clinical and radiological evidence of cardiac damage were observed in 58 cases (1.21%); none of these patients developed clinical evidence of cardiac damage; and eight patients developed clinical and radiology evident changes of heart failure, neither of they showed previous abnormalities in surveillance studies. Multivariate analysis did not show any statistically difference, even in patients whose received > 450mg/m2. Conclusion: The use of surveillance studies did not predict early cardiac damage and will not be used as surveillance tests. Now resources will be developed, because the risk of cardiac damage secondary to anthracyclines remains constant.
Reference12 articles.
1. Defining cardiovascular toxicity of cancer therapy;Herrmann;Eur Heart J,2022
2. Oliva S, Pozzoviul A, Gerards C, et al. Late cardiovascular sequels and long-term monitoring in classical Hodgkin lymphoma and diffuse large B-cell lymphoma survivors. Cancers. 2012:14:61.
3. ArmerianSH, Mertens L, Slorach C, et al. Prevalence of anthracycline related cardiac dysfunction in long-term survivors of adult to onset lymphoma . Cancer. 2018:124(4):850-857.
4. Baech J, Hansen ST, Lund PE, et al. Cumulative anthracyclines exposure and risks of cardiotoxicity . Br J Haematol. 2015:183(5):717-726.
5. Kang Y, Fei X, Chen H, et al. Subclinical anthracyclines in the long-term follows of lymphoma survivors. Arq Bras Cardiol. 2018:110(3):219-225.