Application of actinomycetes in the control of Salmonella species

Abstract

This review is purposed to highlight the potential of finding novel antibiotics by screening various metabolites of actinomycetes. A significant global issue is drug-resistant bacteria and fungi that cause infectious illnesses. The emergence of multi-drug resistant Salmonella species have caused immense public health concern due to the resulting negative impacts. Salmonella causes foodborne illnesses, which result in significant monetary loss and a high death rate. The majority of Salmonella species are zoonotic infections, meaning they can spread from animals to people when they consume tainted meat, animal products, or other food items that have been contaminated with excrement from other animals. The overuse of antibiotics in treating Salmonella infections has increased the urgency to search for new potential sources of effective antibiotics. Actinomycetes are a group of bacteria species found in soil that create vital biological products, primarily powerful antibiotics. actinomycetes make up about two-thirds of all antibiotics, with Streptomyces species producing the majority of them. Several studies have shown that there is an abundant of potent antibiotics produced by actinomycetes. These bioactive compounds have been extensively demonstrated to cause bactericidal and bacteriostatic activities. Thus, more intensity should be put into unraveling more potential antibiotics from actinomycetes to help reduce the burden of drug resistance.