Author:
Eddib Intissar,Barhoumi Lassaad,Mahmoudi Ahmed,Ben Nasr Hmed
Abstract
Thyroidal dysfunction is a risk factor for the development of many metabolic disorders and pathologies. In this work we evaluated the status of the oxidative stress in hypo- and hyperthyroidism, as a sign for developing associated diseases. A total of 44 participants have been recruited and distributed into three groups: Euthyroidism (6), Hypothyroidism (29) and hyperthyroidism (9). Their hematological and biochemical parameters were diagnosed. Free thyroxin 4 (FT4) and thyroid stimulating hormone (TSH) were determined using Elisa kits. Malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD) and glutathione (GSH) were measured in plasma samples by spectrophotometric methods. Our results showed an increase in lipid peroxidation in both hypo- and hyperthyroidism (1.14 ±0.631 µmol. L-1 and 0.904 ±0.179 µmol. L-1 , respectively) in comparison to normal cases (0.821 ±0.173 µmol.L-1 ). Our findings highlight the misbalance of the oxidative stress occurrence in hypo- and hyper-thyroidism due to the subsequent metabolic rate disturbances.
Reference24 articles.
1. Guerri G, Bressan S, Sartori M, et al. Hypothyroidism and hyperthyroidism. Acta Biomed. 2019;90(Suppl 10-S):83-86.
2. Hughes K, Eastman C. Thyroid disease: Long-term management of hyperthyroidism and hypothyroidism. Aust J Gen Pract. 2021;50(1-2):36-42.
3. Inoue K, Ritz B, Brent G, et al. Association of subclinical hypothyroidism and cardiovascular disease with mortality. JAMA Netw Open. 2020;3(2):e1920745.
4. Prevalence of hyperthyroidism, hypothyroidism, and euthyroidism in thyroid eye disease: a systematic review of the literature;Muñoz Ortiz;Syst rev,2020
5. Occurrence of hypothyroidism, diabetes mellitus, and celiac disease in Emirati children with Down's syndrome;Abdulrazzaq;Oman Med J,2018