Abstract
Music has various power for human body and mind. For 12 music tone, two types of scales are Pythagorean Tuning (just intonation) and equal temperament. This minute difference may generate human feeling for music. Music with 528Hz frequency has been in focus as healing music, which is called as “solfeggio frequency music”. Certain frequency music has been known such as 96, 432, 528, 639, 852 Hz, that contributes reducing tension and anxiety. It seems to show beneficial efficacy, but scientific evidence is not enough. Similar to former Mozart effect, further accumulation of evidence and research development will be expected.