Drug handling by elderly kidney: a prospective review to senile kidney physiology

Abstract

Many organs' functional reserve tends to deteriorate as we age. In particular, elderly people have lower lean body mass, serum albumin levels, hepatic perfusion, and filtration rate of residual glomeruli. Furthermore, comorbid processes frequently affect renal patients, who are treated with a variety of medications. Some drug interactions are also altered by the aging process, such as the affinity and number of receptors for certain drugs, as well as cell responses to receptor activation. As a result, Patients with kidney disease who are elderly are more prone to experience adverse drug reactions. The lack of available information on the pharmacokinetic/dynamic profiles of a large number of daily used drugs makes planning a safe pharmacological regimen difficult in this patient group. Finally, many elderly patients are unintentionally disobedient. We will go over the physiological aspects of drug administration in aging kidneys in this literature review.