First case of simultaneous liver-kidney transplant in a patient with primary hyperoxaluria in the state of Santa Catarina - Brazil

Author:

Gaertner Nogara Maria Victoria,Nascimento Vinicius,Stulp Vieira Maria Augusta,Strasser Adrilli,Nogara Marcelo

Abstract

Primary hyperoxaluria (PH) is a rare disorder, resulting from an excessive production of calcium oxalate mainly by the liver, which can be deposited in different organs. Patients affected by PH can progress to recurrent lithiasis, nephrocalcinosis and end-stage renal disease, requiring a kidney transplant for the recovery of organ function, associated with liver transplantation, to correct the source of this metabolic defect.1 The case of MJB, female, 27 years old, was reported in this paper, which is the first recorded case of simultaneous transplantation of this nature in the transplant service of Hospital Santa Isabel - Blumenau and consequently the first in the state of Santa Catarina, Brazil. She discovered the disorder through genetic sequencing at the age of 24.2 The patient had already been on renal replacement therapy, hemodialysis, for 4 years. Due to the severe complications of the disease, simultaneous kidney and liver transplantation was indicated. Considering the evolution of the patient up to the present moment, the transplant in this case proved to be a very effective therapeutic alternative, and in agreement with the literature.1,3

Publisher

MedCrave Group Kft.

Reference9 articles.

1. Rios John Fredy Nieto, Zuluaga M, Higuita LMS, et al. Primary hyperoxaluria diagnosed after kidney transplantation: report of two cases and review of the literature. Brazilian Journal of Nephrology. 2017;39(4):462-466.

2. Hospital santa isabel rede santa catarina. Specialty transplants. 2023.

3. Primary oxalosis diagnosed after kidney transplantation case report;almeida;Brazilian Journal of Transplantation,2007

4. Borges Karen Caires. Double liver and kidney transplantation: case report and literature review. 2013.

5. Brazilian transplant registry, abto. 2023.

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