Design, formulation and characterization of oral disintegrating tablets for lamotrigine

Author:

Gunda Raghavendra Kumar

Abstract

Objective: The purpose of present investigation to formulate, characterize the oral dissolving tablets (ODT) for Lamotrigine. Lamotrigine, an antiepileptic agent, belongs to type –II as per Biopharmaceutical Classification System (BCS). Methods: ODT formulations of Lamotrigine were prepared using different quantities of Sodium Starch Glycolate & Crospovidone employed as Super disintegrants by Direct Compression technique. Nine trials were formulated and evaluated for Pharmaceutical Product Performance. Results: Results shows that all the formulations were lie within the acceptance criterion and the In-vitro dissolution profiles were subjected to kinetic modeling. Conclusion: Formulation (F4) containing 35 mg of Sodium Starch Glycolate & 40 mg of Crospovidone was found to be best one among all and also similar to the Marketed product (LAMICTAL-25) (f2=73.17, f1=3.65 & No significant difference, t=0.0218) to marketed product. Formulation (F4) follows First order, Higuchi’s kinetics, mechanism of drug release was found to be Non-Fickian Diffusion (n= 0.554).

Publisher

MedCrave Group, LLC

Subject

General Medicine

Reference23 articles.

1. K Kavitha, KumuthaSubramaniam, BoeyJiaHui, et al. Potential Drug Candidates for Fast Dissolving Drug Delivery - A Review. Res J Pharm Bio Chem Sci. 2013;4(4):1510-1526.

2. Sehgal P, Gupta R, Umesh Kumar S, et al. Fast Dissolving Tablets: A New Venture in Drug Delivery. Amer J Pharm Tech Res. 2012; 2(4):252-279.

3. Raghavendra Kumar Gunda JN, Suresh Kumar, S Jayakumari, et al. Formulation Development and Evaluation of Risperidone Fast Dissolving Tablets. J Pharm Res. 2010; 10(9): 579-588.

4. David E, Armen HT, Ethrin JA, et al. Principles of pharmacology: The pathophysiologic basis of drug therapy. New Delhi: Wolters Kluwer (India) Pvt Ltd. 2008:815.

5. Rajeev soni, Galividyasagar. Design and development of quick dissolving tablet Containing loratadine by direct compression method. Int J Pharm Chem Bio Sci. 2013;3(3):771-800.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3