The influence of the disk pump of assisted circulation of the left ventricular bypass on hemolytic blood parameters

Author:

Olegovna Golovina Katerina,Mikhailovich Golovin Alexander,Idelevich Aizman RomanORCID

Abstract

Over the past two decades, rotary circulation pumps have been effectively used to treat patients suffering from chronic heart failure (CHF). However, prolonged contact of blood cells with a foreign surface of the pump can cause hemolysis, thrombosis, bleeding and other disorders. A possible solution to reduce the level of blood cells damage may be the introduction into clinical practice the pumps for maintaining blood circulation with a lower rotor speed - 2000-3000 rpm The purpose of this study was to study the effect of a developed by us disk pump for auxiliary circulation of the left ventricular bypass on hemolytic blood parameters. Methods: A study of the effect of a disk pump of auxiliary blood circulation on human donor blood parameters was conducted using a special simulation stand (n=6) and experiments on laboratory animals (n=3). Results: In studies on donated blood, the level of free hemoglobin (FreeHb) was 0.03±0.1 g/l for 4 hours of the experiment. In animal studies, in the first two days after implantation of the pump, an increase in FreeHb was observed in the range from 0.01±0 to 0.05±0.1 g/l. Further, from the third day to the end of observation, fluctuations in FreeHb in the blood were in the range of 0.03–0.04 g/l. During the same period (1-3 days), there was a significant decrease in hematocrit (Hct), which was restored to background values by the 4th day. The concentrations of sodium, calcium, chlorine ions and blood pH remained virtually unchanged throughout the experiment, and the concentration of potassium tended to increase by the 5th-7th day. Conclusion: The developed prototype of a disc-type auxiliary blood circulation pump for left ventricular bypass did not cause significant hemolytic, electrolyte and acid-base disorders in the blood during 240 minutes of experiment on the stand (in vitro) and during 7 days in an in vivo experiment. It allows to recommend this type of pump for short-term use as a promising heart replacement like a “bridge” to organ transplantation or for unloading the heart in patients with CHF.

Publisher

MedCrave Group Kft.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3