Turmeric black tea as a multimodal theronostic dietary adjuvant aiding neuroprotection and ameliorating hypertension

Abstract

This study reports the multifunctional potentiality of turmeric black tea (TBT) in alleviating hypertension in salt induced hypertensive animal model and aiding neuroprotection in colchicines induced Alzheimer rat models. TBT prepared basing on the desirability function of central composite design with 3.11g of black tea and 1.46g of ground turmeric exhibited optimal pharmacologic response and organoleptic acceptability. No signs of mortality were observed till 10g/kg b.w. or any hepato-renal adversities with 5000mg/kg doses. LCMS analysis of TBT showed the presence of several tea catechins, theaflavins, gallic acids and curcuminoids. Incorporation of turmeric in black tea aided in value addition as evidenced by in vitro and in vivo experimental results and has not affected the chemoprofile of black tea studied by FTIR. The multipotency of TBT is attributed due to presence of the variant pharmacologically active molecules.