Harnessing the potential of antimicrobial peptides: current advances and future applications

Abstract

Antimicrobial peptides (AMPs) represent a promising class of naturally occurring molecules with diverse structures and functions, offering a potent defense mechanism against microbial pathogens. This review explores the multifaceted role of AMPs in combating infections and their potential applications in various fields, including medicine, agriculture, and biotechnology. We discuss the mechanisms of action of AMPs, their structural diversity, modes of synthesis, and recent advancements in enhancing their stability and efficacy. Furthermore, we highlight the therapeutic potential of AMPs in treating multidrug-resistant infections, their role as alternatives to conventional antibiotics, and their applications in wound healing, immunomodulation, and drug delivery systems. Additionally, we examine the challenges associated with the clinical translation of AMPs and propose strategies to overcome these hurdles. Overall, this review underscores the importance of AMPs as versatile antimicrobial agents and emphasizes their potential to address the growing threat of antibiotic resistance.