Hypospadiasis előfordulása öt fivérben

Author:

Mavrogenis Stelios1,Czeizel Endre2

Affiliation:

1. Uro-onkológiai Osztály, Országos Onkológiai Intézet Budapest

2. Genetikai Tanácsadó, „Genetikai Ártalmak Társadalmi Megelőzése” Alapítvány Budapest, Törökvész lejtő 32., 1026

Abstract

The healthy couple had five sons with hypospadias (glandular 1, coronal 4) without other child. Similar familial cluster has not reported in the sons of European parents without consanguinity. Mild form androgen insensitivity syndrome was expected in these 5 boys because of the X-linked androgen receptor gene, however, sequencing of the entire coding region (exons 1-8) and all intron-exon boundaries of the androgen receptor gene did not reveal abnormality and the CAG repeat was found in the normal range (21 repeats). This extreme familial cluster may help us to elucidate gene polymorphisms in the polygenic background of the multifactorial origin of isolated hypospadias. Therefore, the authors collaborate with a genetic institute in Pittsburg, USA to perform whole genome sequencing in these probands and their parents. Orv. Hetil., 2015, 156(33), 1348–1352.

Publisher

Akademiai Kiado Zrt.

Subject

General Medicine

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