The efficacy of the bio-electro-magnetic-regulation therapy and pentoxifylline treatment in peripheral arterial stenosis

Abstract

Introduction: There are limited therapeutic options to improve microcirculation. Aim: The question of the study was to investigate any potential beneficial effect of bio-electro-magnetic-regulation therapy on microcirculation in patients suffering from peripheral arterial stenosis including the circulation of lower extremities, as well as intermittent claudication. Method: Thirty patients suffering from peripheral arterial stenosis (Fontaine IIa and IIb) were recruited. The first step of the study was to determine the pain free and maximal walking distance with a treadmill unit. After the placebo period patients received 8 and 20 minutes bio-electro-magnetic-regulation treatment 16 times. After the treatment the pain free and maximal walking distance were measured again. In the second stage of the study the patients were treated by pentoxifylline infusions. Results: bio-electro-magnetic-regulation treatment increased the pain free period by 57.4% (p = 0.005) and the maximal walking distance by 36.6% (p = 0.042). The two forms of therapy together increased the pain free and maximal walking distance by 81.9% and by 84.0%, respectively. The combined therapy was very effective in contrast to placebo and bio-electro-magnetic-regulation treatment (p = 0.000373 and p = 0.00741, respectively). Conclusions: The bio-electro-magnetic-regulation therapy mainly affected the microvessels and pentoxifylline therapy rather had beneficial effects on hemoreology. The clinical effectiveness of combined therapy was good or excellent in 70% of patients. Orv. Hetil., 154 (42), 1674–1679.