Impact of vitamin C on the development, differentiation and functional properties of T cells

Author:

Sasidharan Nair Varun12,Huehn Jochen1ORCID

Affiliation:

1. Department Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany

2. Genetics and Epigenetics of Behavior, Italian Institute of Technology, Via Morego 30, 16163 Genova, Italy

Abstract

AbstractVitamin C plays a multifaceted role in various biological processes and is well-known to facilitate pleiotropic activities in both innate and adaptive immune responses, where the antioxidant capacity of vitamin C is most likely highly relevant since immune responses mainly occur in reducing environments. Beyond its antioxidant properties, vitamin C can enhance the transcription potential of genes by promoting DNA demethylation through ten-eleven-translocation (Tet) methylcytosine dioxygenases, which have been recently demonstrated to be critical for the development and differentiation of T cells. In this minireview, we will provide a broader overview on the impact of vitamin C on signaling and regulatory activities in both innate and adaptive immune cells. Particularly, we will summarize recent findings on the decisive role of finely tuned vitamin C concentrations for T cell development, T helper cell differentiation, and optimal T cell-mediated immune responses.

Funder

HZI Foundation

Publisher

Akademiai Kiado Zrt.

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1. Editorial: Vitamin C from bench to bedside;Frontiers in Nutrition;2024-04-29

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