Vitamin D and breast cancer

Author:

Nagykálnai Tamás1,Landherr László2,Nagy András Csaba3

Affiliation:

1. Bajcsy-Zsilinszky Kórház XVII. ker. Onkológiai Gondozó Budapest

2. Uzsoki Utcai Kórház Fővárosi Onkoradiológiai Központ Budapest

3. Uzsoki Utcai Kórház I. Belgyógyászat Budapest

Abstract

The active form of vitamin D, in conjunction with his own receptor, affect a multitude of biological processes in the cell (inter alia it influences the expression of oncogenes and tumor suppressor genes). There is an increasing volume of scientific publications examining the relationships between serum vitamin D levels, vitamin D supplementation and malignant diseases. Some articles suggest inverse relationship between the low serum levels of vitamin D and the breast cancer risk and mortality, whilst other publications do not support this view. Thus the present opinion is conflicted. Vitamin D can exert a beneficial influence on the symptoms and outcomes of a large number of ailments, but its role in affecting cancer is still not completely clear. Orv. Hetil., 2014, 155(28), 1091–1096.

Publisher

Akademiai Kiado Zrt.

Subject

General Medicine

Reference33 articles.

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2. Carlberg, C., Campbell, M. J.: Vitamin D receptor signaling mechanisms: Integrated actions of a well-defined transcription factor. Steroids, 2013, 78(2), 127–136.

3. Guo, J., Liu, Z. S.: Multiple effects of vitamin D. Chin. Med. J., 2013, 126(15), 2978–2983.

4. Welsh, J.: Cellular and molecular effects of vitamin D on carcinogenesis. Arch. Biochem. Biophys., 2012, 523(1), 107–114.

5. Lakatos, P., Speer, G.: Vitamin D: biological and clinical effects. [A D-vitamin biológiai és klinikai hatásai.] Lege Artis Medicinae, 2002, 12(1), 8–17. [Hungarian]

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