Paroxysmalis nocturnalis haemoglobinuriával szövődött várandósság ritka esete

Author:

Horányi Dániel1,Várkonyi Andrea2,Nagy Gyula Richárd3,Bodó Imre2,Masszi Tamás2

Affiliation:

1. Szülészeti és Nőgyógyászati Osztály, Egyesített Szent István és Szent László Kórház Budapest, Nagyvárad tér 1., 1097

2. Hematológiai és Őssejt-transzplantációs Osztály, Egyesített Szent István és Szent László Kórház Budapest

3. I. Szülészeti és Nőgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest

Abstract

Paroxysmal nocturnal hemoglobinuria is a rare hematological disease. It is associated with increased maternal and fetal complications to such an extent that pregnancy has been considered relatively contraindicated in woman with paroxysmal nocturnal haemoglobinuria. Recently, eculizumab, a monoclonal antibody, has been shown to decrease complications during pregnancies. The highest risk is thromboembolic complication and, therefore, anticoagulant is a standard therapy during pregnancy. In the presented case, a 29-year-old woman with a 5-year history of paroxysmal nocturnal haemoglobinuria had a pregnancy. It was her first pregnancy and was complicated by a sinus thrombosis at the 11th gestational week. After the introduction of eculizumab treatment, the remaining period of pregnancy and delivery were uncomplicated. There are only a few cases in the literature about pregnancy in woman with paroxysmal nocturnal hemoglobinuria who are treated with eculizumab. This monoclonal antibody seems to be safe and it likely prevents many of the complications otherwise observed. Orv. Hetil., 2016, 157(23), 916–918.

Publisher

Akademiai Kiado Zrt.

Subject

General Medicine

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