Debilitating progressive encephalitis in a patient with BTK deficiency-Reference-Cited by-同舟云学术

Debilitating progressive encephalitis in a patient with BTK deficiency

Published:2012-09-01 Issue:3 Volume:59 Page:335-342
ISSN:1217-8950
Container-title:Acta Microbiologica et Immunologica Hungarica
language:
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Author:

Mohammadzadeh Iraj¹,Yeganeh Mehdi²,Khaledi Mojdeh³,Salehiomran Mohammad¹,Aghamohammadi Asghar³,Rezaei Nima

Affiliation:

1. 1 Babol University of Medical Sciences Non-Communicable Pediatric Diseases Research Center Babol Iran

2. 2 University of Sherbrooke, Centre de Recherche Clinique Etienne Le-Bel, Centre Hopitalier Universitaire de Sherbrooke Division of Immunology, Department of Pediatrics, Faculty of Medicine Sherbrooke QC J1H 5N4 Canada

3. 3 Tehran University of Medical Sciences Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center Tehran Iran

Abstract

X-linked agammaglobulinemia (XLA), also known as Bruton’s tyrosine kinase(BTK)deficiency, is a primary antibody deficiency, characterized by low number of B cells, agammaglobulinemia and increased susceptibility to a variety of infections. Herein, we report a case of XLA with confirmedBTKmutation that developed neurological deficits. While we could not detect any responsible microorganism in spite of comprehensive workup, brain magnetic resonance imaging revealed moderate brain atrophy. The diagnosis of progressive encephalitis was made for this patient. Patients with XLA have a higher chance of encephalitis compared with other primary antibody deficiencies. Given the violent nature of encephalitis, it is a concern among XLA patients.

Publisher

Akademiai Kiado Zrt.

Subject

General Immunology and Microbiology,General Medicine

Link

https://akjournals.com/downloadpdf/journals/030/59/3/article-p335.xml

Reference32 articles.

1. Linkage analysis and physical mapping near the gene for X-linked agammaglobulinemia at Xq22;Parolini O.;Genomics,1993

2. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases;Vetrie D.;Nature,1993

3. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia;Tsukada S.;Cell,1993

4. Pathogenesis, diagnosis, and management of primary antibody deficiencies and infections;Fried A. J.;Clin Microbiol Rev,2009

5. Clinical, immunological and molecular characteristics of 37 Iranian patients with X-linked agammaglobulinemia;Aghamohammadi A.;Int Arch Allergy Immunol,2006

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