Affiliation:
1. Debreceni Egyetem, Klinikai Központ, Általános Orvostudományi Kar Belgyógyászati Intézet, Hematológiai Tanszék Debrecen Nagyerdei krt. 98. 4032
Abstract
Treatment of autoimmune haemolytic anaemia is still a challenge to clinicians. Even today it may be lethal. Half of the cases are secondary due to an underlying disease, and the others are primary or idiopathic cases. According to the specificity and type of autoantibodies there are warm and cold type forms of autoimmune haemolytic anaemia. The hallmark of the diagnosis is to detect the presence of haemolysis by clinical and laboratory signs and detect the underlying autoantibodies. Treatment of autoimmune haemolytic anaemia is still a challenge to clinicians. We still loose patients due to excessive haemolysis or severe infections caused by immunosuppression. First line treatment is corticosteroids. Other immunosuppressive agents like: cyclophosphamide, azathioprine, cyclosporine or the off label rituximab can be used in case of corticosteroid refractoriness. Splenectomy is a considerable option in selective cases. The authors discuss treatment options and highlight difficulties by presenting 4 cases. Orv. Hetil., 2015, 156(11), 449–456.
Reference29 articles.
1. Packman, C. H.: Hemolytic anemia due to warm autoantibodies. Blood Rev., 2008, 22(1), 17–31.
2. Gehrs, B. C., Friedberg, R. C.: Autoimmune hemolytic anemia. Am. J. Hematol., 2002, 69(4), 258–271.
3. Lambert, J. F., Nydegger, U. E.: Geoepidemiology of autoimmune hemolytic anemia. Autoimmun. Rev., 2010, 9(5), A350–A354.
4. Hoffbrand, V., Moss, P., Pettit, J.: Essential Haematology (Essentials). 5th ed. Wiley-Blackwell, Hoboken, 2006.
5. Hoffman, P. C.: Immune hemolytic anemia – selected topics. Hematology Am. Soc. Hematol. Educ. Program, 2009, 2009, 80–86.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献