Ochratoxin A content of urine samples of healthy humans in Hungary

Author:

Fazekas B.1,Tar Andrea2,Kovács Melinda3

Affiliation:

1. 1 Veterinary Institute of Debrecen H-4031 Debrecen, Bornemissza u. 3-5, Hungary

2. 2 Veterinary Institute of Debrecen H-4031 Debrecen, Bornemissza u. 3-5, Hungary

3. 3 Animal Breeding and Animal Hygiene Research Group of the Hungarian Academy of Sciences and the University of Kaposvár, Faculty of Animal Science, University of Kaposvár Kaposvár, Hungary

Abstract

The ochratoxin A (OTA) content of urine samples from 88 healthy humans living at five settlements in three counties of Hungary was determined by immunoaffinity column cleanup and high-performance liquid chromatography (HPLC). OTA was detected in 61% of the samples in an average concentration of 0.013 ng/ml (range: 0.006-0.065 ng/ml). OTA concentrations measured in urine samples from men and women were not significantly different. The OTA concentration of samples from Heves county was significantly (t-test; p < 0.003) higher than that of samples from Hajdú-Bihar and Somogy counties. The regional differences in OTA concentration of urine samples indicate regional differences in the OTA exposure of the human population. Further studies are necessary to determine the cause of the regional differences in the OTA intake. The studies allow us to conclude that the OTA intake of the majority of the Hungarian population is low (< 1 ng/kg of body weight per day) but a certain part of the rural population may take up higher levels of OTA.

Publisher

Akademiai Kiado Zrt.

Subject

General Veterinary

Reference21 articles.

1. Commission Regulation (EC) No 472/2002 of 12 March 2002. Official Journal of the European Communities, 16.3.2002.

2. A French monitoring programme for determining ochratoxin A occurrence in pig kidneys;S. Dragacci;Nat. Toxins,1999

3. Ochratoxin A contamination of cereal grains and coffee in Hungary in the year 2001;B. Fazekas;Acta Vet. Hung.,2002

4. Assessment of dietary exposure to ochratoxin A in the UK using a duplicate diet approach and analysis of urine and plasma samples;J. Gilbert;Food Addit. Contam.,2001

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