Verapamil Ameliorates Motor Neuron Degeneration and Improves Lifespan in the SOD1G93A Mouse Model of ALS by Enhancing Autophagic Flux-Reference-Cited by-同舟云学术

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Verapamil Ameliorates Motor Neuron Degeneration and Improves Lifespan in the SOD1G93A Mouse Model of ALS by Enhancing Autophagic Flux

Published:2019 Issue:6 Volume:10 Page:1159
ISSN:2152-5250
Container-title:Aging and disease
language:en
Short-container-title:Aging and disease

Author:

Zhang Xiaojie,Chen Sheng,Lu Kaili,Wang Feng,Deng Jiangshan,Xu Zhouwei,Wang Xiuzhe,Zhou Qinming,Le Weidong,Zhao Yuwu

Publisher

Aging and Disease

Subject

Cell Biology,Neurology (clinical),Geriatrics and Gerontology,Pathology and Forensic Medicine

Link

http://www.aginganddisease.org/fileup/2152-5250/PDF/ad-0-0-0-1903030956-1.pdf

Reference63 articles.

1. Brown RH, Al-Chalabi A (2017). Amyotrophic lateral sclerosis. N Engl J Med, 377: 162-172.

2. Gordon PH, Cheng B, Katz IB, Pinto M, Hays AP, Mitsumoto H, et al (2006). The natural history of primary lateral sclerosis. Neurology, 66: 647-653.

3. Gordon PH (2013). Amyotrophic Lateral Sclerosis: An update for 2013 Clinical Features, Pathophysiology, Management and Therapeutic Trials. Aging Dis, 4: 295-310.

4. Bosco DA, Morfini G, Karabacak NM, Song Y, Gros-Louis F, Pasinelli P, et al (2010). Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nat Neurosci, 13: 1396-1403.

5. Vidal RL, Matus S, Bargsted L, Hetz C (2014). Targeting autophagy in neurodegenerative diseases. Trends Pharmacol Sci, 35: 583-591.

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