Men's Reproductive Health: Oxidative Stress and the Effectiveness of Antioxidant Therapy

Abstract

This review article surveys and summarizes the literature data concerning the problems of deterioration of the main indicators of men's reproductive health and the effectiveness of therapy with drugs with antioxidant properties. The analysis of domestic and foreign literature confirms that oxidative stress (OS) accompanies and/or is one of the pathogenetic links in the development of many types of reproductive pathology in men. The health status of the male population is influenced by the following factors: lifestyle, existing diseases, the state of the environment, and the genotype of the population. The interaction of several weak, but unidirectional, factors creates a high risk of developing male reproductive pathology. The polyetiological nature of fertility disorders in men causes certain difficulties in creating adequate methods of treating this pathology and causes multicomponent biocomplexes to appear on the pharmaceutical market that contain active substances that can affect the quality of the ejaculate.