Topology of Chromosomes 18 and X in Human Blastomeres from 3- to 4-Day-old Embryos-Reference-Cited by-同舟云学术

Topology of Chromosomes 18 and X in Human Blastomeres from 3- to 4-Day-old Embryos

Published:2005-03 Issue:3 Volume:53 Page:273-276
ISSN:0022-1554
Container-title:Journal of Histochemistry & Cytochemistry
language:en
Short-container-title:J Histochem Cytochem.

Author:

Diblík Jan¹,Macek Milan¹,Magli Maria-Cristina²,Krejčí Roman³,Gianaroli Luca²

Affiliation:

1. Center of Reproductive Genetics, Institute of Biology and Medical Genetics, Charles University, 2nd School of Medicine, University Hospital Motol, Prague, Czech Republic

2. Società Italiana Studi di Medicina della Riproduzione, Bologna, Italy

3. Department of Genetics and Microbiology, Charles University, Faculty of Science, Prague, Czech Republic

Abstract

The positions of chromosomes 18 and X fluorescence in situ hybridization signals were analyzed in blastomeres generated from human in vitro fertilization 3- to 4-day-old embryos after preimplantation screening of aneuploidy of chromosomes 13, 16, 18, 21, 22, X, and Y. Fluorescent signal localization compared with a three-dimensional sphere model of random signal distribution revealed significant differences, providing evidence of peripheral localization of chromosome 18 in aneuploid ( p=0.0013) and aneuploid/euploid blastomeres ( p=0.0011). No differences were found in localization of chromosome 18 in euploid and in chromosome X in euploid and aneuploid blastomeres.

Publisher

SAGE Publications

Subject

Histology,Anatomy

Link

http://journals.sagepub.com/doi/pdf/10.1369/jhc.4B6509.2005

Reference6 articles.

1. The Duration of Replication of the Inactive X Chromosome in Humans Based on the Persistence of the Heterochromatic Sex Chromatin Body During DNA Synthesis

2. Radial Arrangement of Chromosome Territories in Human Cell Nuclei: A Computer Model Approach Based on Gene Density Indicates a Probabilistic Global Positioning Code

3. Double locus analysis of chromosome 21 for preimplantation genetic diagnosis of aneuploidy

4. Nuclear chromosomal localization in human preimplantation embryos: correlation with aneuploidy and embryo morphology

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2. Nuclear organisation in totipotent human nuclei and its relationship to chromosomal abnormality;Journal of Cell Science;2008-03-01

3. Chromosome topology in normal and aneuploid blastomeres from human embryos;Prenatal Diagnosis;2007-09-12