Polypyrrole - A Potential Candidate for Stimulated Nerve Regeneration

Author:

Shastri V. R.,Schmidt C. E.,Kim T.-H.,Vacanti J. P.,Langer R.

Abstract

AbstractThe proposed research is aimed at gaining a fundamental understanding of in vitro nerve cellbiomaterials interactions, with the immediate goal of engineering materials to specifically enhance expression of the neuronal phenotype. Long term goals include (1) optimizing the innervation (connection) of the host neurons with implanted bioartificial tissue constructs and, (2) facilitating the regeneration of damaged peripheral and central nerves. In this study, the interactions of neuronal like PC-I12 cells with the electrically conducting polymer, polypyrrole, (PP) have been investigated. It has been shown by quantitative image analysis that neurite extensions of PC-12 cells are more pronounced on PP surfaces as compared to tissue culture polystyrene. Application of an electrical stimulus to cells cultured on PP film significantly increased (based on morphological evaluation) the expression of neurites in these cells compared to controls. Tissue compatibility and transected sciatic nerve regeneration studies in rat models show that PP films invoke little negative response and support nerve regeneration.

Publisher

Springer Science and Business Media LLC

Subject

General Engineering

Reference16 articles.

1. Changes in cell shape and actin distribution induced by constant electric fields

2. Neurites grow faster towards the cathode than the anode in a steady field

3. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

4. 11. The PLGA films were cast from a solution (100 mg/ml) in dichloromethane into 30 ml beakers (1 ml per beaker, 7.55 cm 2). After 24 hours the films were removed from the bottom of the beakers by floating them off in water. The free floating films were then dried under vacuum for 24 hours before further use.

5. 9. Shastri V. R. , Ph. D. Thesis, Rensselaer Polytechnic Institute, 1995.

Cited by 19 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. A stretchable, electroconductive tissue adhesive for the treatment of neural injury;Bioengineering & Translational Medicine;2024-05-03

2. Endogenous Electric Signaling as a Blueprint for Conductive Materials in Tissue Engineering;Bioelectricity;2021-03-01

3. The effect of nanoscale surface electrical properties of partially biodegradable PEDOT-co-PDLLA conducting polymers on protein adhesion investigated by atomic force microscopy;Materials Science and Engineering: C;2019-06

4. Electroactive Polymeric Materials;Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials;2017-08-16

5. Conducting Polymers;Encyclopedia of Biomedical Polymers and Polymeric Biomaterials;2016-01-26

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3