Synthesis and characterization of polyurethane films based on castor oil-derived polyols with heparin and low-molecular-weight chitosan for cardiovascular implants

Abstract

AbstractApplications of polyurethanes (PUs) depend on several physicochemical factors due to the presence of varied monomers involving several ratios. The present study aimed to synthesize various chitosan/heparin-inserted PUs to examine the addition effect on the mechanical and biological properties of the PU-based polymeric material. The PUs were synthesized from unmodified castor oil and isophorone diisocyanate, including chitosan and heparin as fillers. The FTIR, thermal, and mechanical characterization of materials with and without fillers exhibited properties that can be considered within the accepted values. In addition, considering the non-cytotoxicity and antibacterial activity, these synthesized polymers can be exploited as biomaterials. The results also showed that these PUs offer a competitive advantage over other materials since the observed good mechanical and biological properties were found to be within the optimal range for the biomaterial design to myocardial or vascular tissue engineering. Graphical abstract