Capabilities of Molecular Genetic Methods for Effective Hereditary Cancers Detection in Individuals with High Cancer Risk Factors-Reference-Cited by-同舟云学术

Capabilities of Molecular Genetic Methods for Effective Hereditary Cancers Detection in Individuals with High Cancer Risk Factors

Published:2023-06-19 Issue:2 Volume:4 Page:30-40
ISSN:2713-2617
Container-title:City Healthcare
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Short-container-title:City Healthcare

Author:

Semenova Anna B.¹^ORCID,Byakhova Mariya M.¹^ORCID,Galkin Vsevolod N.¹^ORCID,Parts Sergey A.¹^ORCID,Makarova Maria V.²^ORCID,Nemtsova Marina V.²^ORCID,Chernevskiy Denis K.²^ORCID,Sagaydak Olesya V.²^ORCID,Baranova Elena E.²^ORCID,Belenikin Maxim S.²^ORCID,Krinitsina Anastasia A.²^ORCID,Khatkov Igor E.³^ORCID,Bodunova Natalia A.³^ORCID,Danishevich Anastasia M.³^ORCID,Kanner Dmitry Yu.⁴^ORCID,Savelov Nikita A.⁴^ORCID,Shabunin Alexey V.⁵^ORCID,Lebedev Sergey S.⁵^ORCID,Protsenko Denis N.⁶^ORCID,Gadzhieva Saida M.⁷^ORCID

Affiliation:

1. GBUZ “City Clinical Oncological Hospital No. 1 of Moscow Healthcare Department”

2. OOO “Evogen”

3. GBUZ “Loginov Moscow Clinical Scientific and Practical Center of Moscow Healthcare Department”

4. GBUZ “Moscow City Oncological Hospital No. 62 of Moscow Healthcare Department”

5. GBUZ “Botkin City Clinical Hospital of Moscow Healthcare Department”

6. GBUZ Moscow Multidisciplinary Clinical Center "Kommunarka" of Moscow Healthcare Department”

7. Moscow Healthcare Department

Abstract

Russia and other countries report an increase in the incidence of malignant neoplasms, and approximately 10 % of all oncological cases have hereditary background. Molecular genetic testing in patients with diagnosed malignant neoplasms and a suspected hereditary factor will help to select effective modern methods of treatment and prevention of the development of neoplasms of other localizations. According to the study, 12,6 % of patients had hereditary cancer syndrome, which allowed to administer molecular genetic tests to patients’ relatives. Consequently, it becomes possible to detect hereditary cancer risk factors, improve the efficiency of clinical examination, elaborate and implement programs for prevention and early detection of the disease.

Publisher

Research Institute for Healthcare Organization and Medical Management

Subject

General Medicine

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