Potential Effect of Casein PhosphopeptideAmorphous Calcium Phosphate on Salivary Properties in Patients with Xerostomia: A Narrative Review

Abstract

Changes in the makeup of saliva and/or a reduction in saliva flow are the two main causes of dry mouth. Dental caries, oral fungal infections, difficulty speaking and chewing or swallowing, mucositis, and burning mouth syndrome are associated with xerostomia, all of which have a detrimental effect on the quality of life associated with oral health. Although xerostomia is common in the general population, there are no standardised treatment standards. Recent research has indicated that topical treatments available without a prescription cannot be routinely recommended. Casein Phosphopeptide-Amorphous Calcium Phosphate complexes (CPP-ACP) and Casein Phosphopeptide-Amorphous Calcium Phosphate Fluoride have been shown to play a significant role in reducing dental caries, plaque, and pathological microorganisms, maintaining pH, and treating hypersensitivity. There is insufficient evidence that CPP-ACPs can induce salivation in patients with hyposalivation. This article reviews recent studies on the effect of CPP-ACPs on salivary traits and their use in treating patients with xerostomia.